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Nickel-catalyzed reductive cross-coupling of monofluoroalkyl triflates with aryl halides for monofluoroalkylated arenes

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成果类型:
期刊论文
作者:
Li, Zhi-Heng;Peng, Hao;Zhang, Panke;Hu, Yu-Ang;Pi, Chao;...
通讯作者:
Zhu, CJ
作者机构:
[Peng, Hao; Xu, Hao; Hu, Yu-Ang; Zhu, CJ; Li, Zhi-Heng; Zhu, Cuiju] Cent China Normal Univ, Minist Educ, Coll Chem, State Key Lab Green Pesticide,Engn Res Ctr Photoen, Wuhan 430079, Peoples R China.
[Zhang, Panke; Pi, Chao] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China.
[Zhang, Panke; Pi, Chao] Zhengzhou Univ, Coll Chem, Key Lab Appl Chem Henan Univ, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Peoples R China.
通讯机构:
[Zhu, CJ ] C
Cent China Normal Univ, Minist Educ, Coll Chem, State Key Lab Green Pesticide,Engn Res Ctr Photoen, Wuhan 430079, Peoples R China.
语种:
英文
期刊:
Organic Chemistry Frontiers
ISSN:
2052-4110
年:
2024
卷:
11
期:
18
页码:
5010-5015
基金类别:
National Natural Science Foundation of China [22201089]; Fundamental Research Funds for the Central Universities [CCNU24JCPT013]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
Here, we report a nickel-catalyzed reductive C(sp3)-C(sp2) cross-coupling of monofluoroalkyl triflates with aryl halides, yielding a series of functionalized monofluoroalkylated arenes. This method is characterized by mild reaction conditions, a broad substrate scope, with excellent functional group compatibility. Facile follow-up transformations highlight its utility as an appealing tool in the synthesis of pharmaceutical derivatives. Here, we report a nickel-catalyzed reductive C(sp3)-C(sp2) cross-coupling of monofluoroalkyl triflates with aryl ha...

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