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A novel identified temporal protein complexes strategy inspired by density-distance and brainstorming process

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成果类型:
期刊论文、会议论文
作者:
Shen, Xianjun;Zhou, Jin;Jiang, Xingpeng(蒋兴鹏);Hu, Xiaohua;He, Tingting(何婷婷);...
通讯作者:
Xie, Dan
作者机构:
[Jiang, Xingpeng; Yang, Jincai; He, Tingting; Shen, Xianjun; Hu, Xiaohua; Zhou, Jin] Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.
[Xie, Dan] Hubei Univ Chinese Med, Coll Informat Engn, Wuhan, Peoples R China.
通讯机构:
[Xie, Dan] H
Hubei Univ Chinese Med, Coll Informat Engn, Wuhan, Peoples R China.
语种:
英文
关键词:
protein complex;dynamic protein-protein interaction network;cluster center;gene ontology information;brainstorming process
期刊:
2016 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
ISSN:
2156-1125
年:
2017
页码:
1269-1274
会议名称:
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
会议论文集名称:
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
会议时间:
December 2016
会议地点:
Shenzhen
会议主办单位:
[Shen, Xianjun;Zhou, Jin;Jiang, Xingpeng;Hu, Xiaohua;He, Tingting;Yang, Jincai] Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.^[Xie, Dan] Hubei Univ Chinese Med, Coll Informat Engn, Wuhan, Peoples R China.
会议赞助商:
IEEE, IEEE Comp Soc, Natl Sci Fdn, Harbin Inst Technol
主编:
Tian, T Jiang, Q Liu, Y Burrage, K Song, J Wang, Y Hu, X Morishita, S Zhu, Q Wang, G
出版地:
10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA
出版者:
IEEE
ISBN:
978-1-5090-1612-9
机构署名:
本校为第一机构
院系归属:
计算机学院
摘要:
Detection of protein complexes and functional modules plays a crucial role for strengthening the comprehension of cellular organization and biological functions on the dynamic protein-protein interaction network. In this article, we put forward a new strategy to identify temporal protein complexes. Integrating time-course gene expression data into static protein interaction data, a series of time-sequenced subnetworks were constructed. Then we combined the network topology and gene ontology information for defining the distance between proteins in PPI network. A novel method to find the cluste...

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