RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Shi-Hao;Zhang, Ru-Yan;Zhang, Hai-Wei;Liu, Yan-Ling;Wen, Yu;...

通讯作者：

Yang, Guang-Fu;Guo, Jun;Gong, Rui

作者机构：

[Wang, Jian; Yang, Guang-Fu; Guo, J; Liu, Yan-Ling; Wen, Yu; Yin, Xu-Guang; Zhou, Shi-Hao; Li, Yu-Ting; Zhang, Ru-Yan; Guo, Jun; You, Zi-Wei] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem,Key Lab Pesticide & Chem Bi, Wuhan 430079, Peoples R China.

[Gong, Rui; Zhang, Hai-Wei] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China.

[Qiu, Hong] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China.

通讯机构：

[Yang, GF; Guo, J; Gong, Rui] C

Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem,Key Lab Pesticide & Chem Bi, Wuhan 430079, Peoples R China.

Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China.

语种：

英文

期刊：

Chemical Communications

ISSN：

1359-7345

年：

2022

卷：

期：

页码：

2120-2123

DOI：

10.1039/d1cc06520c

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772056, 22177035]; National Key Research and Development Program of China [2017YFA0505200]; Wuhan Bureau of Science and Technology [2020020601012217, 2020020101010001]; Selfdetermined Research Funds of CCNU from the Colleges' Basic Research and Operation of MOE [CCNU20TS016]; Program of Introducing Talents of Discipline to Universities of ChinaMinistry of Education, China - 111 Project [B17019]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

The coronavirus 2019 (COVID-19) pandemic is causing serious impacts in the world, and safe and effective vaccines and medicines are the best methods to combat the disease. The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in interacting with the angiotensin-converting enzyme 2 (ACE2) receptor, and is regarded as an important target of vaccines. Herein, we constructed the adjuvant-protein conjugate Pam3CSK4-RBD as a vaccine candidate, in which the N-terminal of the RBD was site-selectively oxidized by transaminat...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问