期刊论文

Wu, An-xin（吴安心）

英文

Organic Letters

1523-7060

2017

19

17

4584-4587

10.1021/acs.orglett.7b02182

This work was supported by the National Natural Science Foundation of China (Grant Nos. 21472056 and 21602070). We also thank Dr. Chuanqi Zhou, Hebei University, for analytical support. This work was supported by “The Fundamental Research Funds for the Central Universities” (CCNU15ZX002 and CCNU16A05002). This work was also supported by the 111 Project B17019.

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The iodine-catalyzed catalytic formal [3 + 3 + 1] cycloaddition for the preparation of a seven-membered O-heterocyclic ring is presented, which is an achievement of methyl and carbonyl group reactivity of 3-methyl-5-pyrazolones to forge the Csp3–O bond. This novel protocol provides a straightforward and efficient access to structurally diverse fused O-heterocycles through an iodine-catalyzed iodination/Kornblum oxidation/oxidative coupling/C–O bond formation cascade reaction. This approach demonstrates the unprecedented concurrent realization...