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Copula particle filter algorithm for inferring parameters of regulatory network models with noisy observation data

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成果类型:
期刊论文、会议论文
作者:
Deng, Zhimin*;Zhang, Xingan;Tian, Tianhai
通讯作者:
Deng, Zhimin
作者机构:
[Deng, Zhimin] Guangdong Univ Technol, Sch Appl Math, Guangzhou 510520, Guangdong, Peoples R China.
[Zhang, Xingan] Cent China Normal Univ, Sch Math & Stat, Wuhan 430000, Peoples R China.
[Tian, Tianhai] Monash Univ, Sch Math Sci, Melbourne, Vic 3800, Australia.
通讯机构:
[Deng, Zhimin] G
Guangdong Univ Technol, Sch Appl Math, Guangzhou 510520, Guangdong, Peoples R China.
语种:
英文
关键词:
Parameter inference;Copula particle filter;variance;genetic regulation
期刊:
2016 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
ISSN:
2156-1125
年:
2017
页码:
570-575
会议名称:
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
会议论文集名称:
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
会议时间:
December 2016
会议地点:
Shenzhen, China
会议主办单位:
[Deng, Zhimin] Guangdong Univ Technol, Sch Appl Math, Guangzhou 510520, Guangdong, Peoples R China.^[Zhang, Xingan] Cent China Normal Univ, Sch Math & Stat, Wuhan 430000, Peoples R China.^[Tian, Tianhai] Monash Univ, Sch Math Sci, Melbourne, Vic 3800, Australia.
会议赞助商:
IEEE, IEEE Comp Soc, Natl Sci Fdn, Harbin Inst Technol
主编:
Tian, T Jiang, Q Liu, Y Burrage, K Song, J Wang, Y Hu, X Morishita, S Zhu, Q Wang, G
出版地:
10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA
出版者:
IEEE
ISBN:
978-1-5090-1612-9
基金类别:
Australian Research CouncilAustralian Research Council [FT100100748]
机构署名:
本校为其他机构
院系归属:
数学与统计学学院
摘要:
Biological experimental data normally contain noise due to probabilistic character of biochemical reactions and environmental fluctuations. It has been widely assumed that the observed data is the corresponding system states plus a white noise whose variance is a constant. In addition, all observations are assumed to be independent to each other. However, recently biological studies suggested that the randomness in experimental data may depend on system state and observations of different variables may be highly correlated. To address these issues, this work proposes a new model in which the v...

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