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Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics

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成果类型:
期刊论文
作者:
Li, Jun;Zhang, Yi;Wang, Pengzhan;Yu, Le;An, Jusung;...
通讯作者:
Deng, Ganzhen;Sun, Yao;Kim, Jong Seung
作者机构:
[Li, Jun] Huazhong Agr Univ, Coll Sci, Dept Chem, Wuhan 430070, Peoples R China.
[Deng, Ganzhen] Huazhong Agr Univ, Coll Anim Sci & Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.
[Zhang, Yi; Sun, Yao] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
[An, Jusung; Kim, Jong Seung; Yu, Le] Korea Univ, Dept Chem, Seoul 02841, South Korea.
[Wang, Pengzhan] Hubei Univ, Key Lab Synth & Applicat Organ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ,Funct Mol, Wuhan 430062, Peoples R China.
通讯机构:
[Deng, Ganzhen] H
[Sun, Yao] C
[Kim, Jong Seung] K
Huazhong Agr Univ, Coll Anim Sci & Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.
Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Activable AIEgens;Aggregation-induced emission;Fluorescence Imaging;Small-molecule dye;Theranostics
期刊:
Coordination Chemistry Reviews
ISSN:
0010-8545
年:
2021
卷:
427
页码:
213559
基金类别:
National Research Foundation of Korea (CRI project) [2018R1A3B1052702, 2019M3E5D1A01068998]; NSFCNational Natural Science Foundation of China (NSFC) [21806048, 31972744]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2662018QD009]; Wuhan Scientific and Technological Projects [2019020701011441]; Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization [2019-LRRRU03]; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology [OHIC2019K01]; Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China [2020ZJUGP003]
机构署名:
本校为通讯机构
院系归属:
化学学院
摘要:
Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (ALE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical rese...

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