A New Urokinase Plasminogen Activator Receptor-Targeted Near-Infrared Fluorescence (NIR) Probe for Glioma Imaging

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成果类型：

期刊论文

作者：

Han, Yunfeng;Tu, Le;Zhang, Yongxue;Liu, Qiuyu;Dong, Qingjian;...

通讯作者：

Dong, QJ;Sun, ZY

作者机构：

[Dong, Qingjian; Han, Yunfeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430030, Peoples R China.

[Han, Yunfeng; Zhang, Yongxue] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430022, Peoples R China.

[Tu, Le] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.

[Liu, Qiuyu; Sun, Ziyan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China.

通讯机构：

[Dong, QJ ; Sun, ZY ] H

Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430030, Peoples R China.

Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China.

语种：

英文

关键词：

glioma;indocyanine green;photothermal imaging;near-infrared fluorescence imaging;urokinase-type plasminogen activator receptor

期刊：

ChemistrySelect

ISSN：

2365-6549

年：

2023

卷：

期：

DOI：

10.1002/slct.202204504

基金类别：

Hubei Province Key Laboratory of Molecular Imaging [2020fzyx011]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

A new fluorescent imaging probe indocyanine green-VC (ICG-VC) in the second near-infrared window (NIR-II) was fabricated based on the urokinase-type plasminogen activator receptor (uPAR) targeted polypeptide VC (VSNKYFSNIHWGC). The relative quantum yield (phi(F))was 0.34 %. The tail of its fluorescence emission wavelength exceeded 1000 nm with excellent photostability. In vitro cell analysis, MTT results indicated the high biocompatibility of ICG-VC with U87MG cells. ICG-VC showed good photothermal conversion behavior and photothermal stability.In vivo NIR-II fluorescence imaging, ICG-VC exhib...

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A New Urokinase Plasminogen Activator Receptor-Targeted Near-Infrared Fluorescence (NIR) Probe for Glioma Imaging

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