期刊论文

中文

应用化学

1000-0518

2007

24

9

1074-1076

10.3969/j.issn.1000-0518.2007.09.023

国家自然科学基金资助项目（20072009）；

本校为第一机构

咔唑经过亚硝基化后在醋酸溶液中用锌粉还原得到9-氨基咔唑,后者在弱酸催化下与不同取代芳醛反应,合成了9种新型的咔唑席夫碱,收率63%～87%.采用红外光谱、核磁共振谱、质谱和元素分析等测试技术确证了它们的结构.初步生物活性测试结果表明,目标化合物具有较好的抗菌活性,其中化合物3和化合物7对测试菌种的抑菌率高于85%.

Carbazole was nitrosylated and reduced to aminoearbazole by the action of zinc in acetic acid. Nine novel earbazole sehiff bases （ 1 - 9） were synthesized by the reaction of 9-aminoearbazole and substituted aromatic aldehydes with yields of 63% -87%. Their structures were characterized by IR, ^1H NMR, MS and elemental analysis. The preliminary test of bioaetivity showed they displayed notable antibacterial activities. The bacterial in...