Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist

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成果类型：

期刊论文

作者：

Chen, Meixia;Wang, Zhuowen;Li, Weiguo;Chen, Yichang;Xiao, Qin;...

通讯作者：

Ji, Xinyue;Liu, YL

作者机构：

[Xiao, Qin; Chen, Yichang; Ji, Xinyue; Shang, Xinci; Ji, XY; Chen, Meixia; Huang, Xiaolei; Liu, Yanli; Wang, Zhuowen] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China.

[Xiao, Qin; Chen, Yichang; Ji, Xinyue; Shang, Xinci; Ji, XY; Chen, Meixia; Huang, Xiaolei; Liu, Yanli; Wang, Zhuowen] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Prov Engn Res Ctr Precis Diagnost & Therap, Suzhou 215123, Jiangsu, Peoples R China.

[Li, Weiguo] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.

[Wei, Zhengguo] Soochow Univ, Sch Biol & Basic Med Sci, Suzhou 215021, Jiangsu, Peoples R China.

通讯机构：

[Ji, XY; Liu, YL ] S

Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China.

Soochow Univ, Coll Pharmaceut Sci, Jiangsu Prov Engn Res Ctr Precis Diagnost & Therap, Suzhou 215123, Jiangsu, Peoples R China.

语种：

英文

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS

ISSN：

1874-9399

年：

2023

卷：

1866

期：

页码：

194962

DOI：

10.1016/j.bbagrm.2023.194962

基金类别：

National Natural Science Foundation of China [32271309]; Priority Academic Program Development of the Jiangsu Higher Education Institutes, China (PAPD); Six talent Professorship of Jiangsu province, China [SWYY-104]; project of Hubei Key Laboratory of Genetic Regulation and Integrative Biology [GRIB202208]

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Tudor domain-containing protein 3 (TDRD3) is involved in regulating transcription and translation, promoting breast cancer progression, and modulating neurodevelopment and mental health, making it a promising therapeutic target for associated diseases. The Tudor domain of TDRD3 is essential for its biological functions, and targeting this domain with potent and selective chemical probes may modulate its engagement with chromatin and related functions. Here we reported a study of TDRD3 antagonist following on our earlier work on the development of the SMN antagonist, Compound 1, and demonstrate...

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Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist

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