National Key Research and Development Program of China [2017YFC0702700]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU17ZDJC05]
机构署名：
本校为第一且通讯机构
院系归属：
生命科学学院
摘要：
Diisodecyl phthalate (DIDP) is considered to be one of the less toxic phthalates. However epidemiological studies suggest that DIDP is associated with the occurrence of asthma. The effect of DIDP exposure on allergic asthma and the underlying mechanism have not been fully elucidated. Here, mice were exposed to DIDP and sensitization with OVA. The results demonstrated that DIDP exposure aggravated allergic asthma. Exposure to 15 mg/kg/day DIDP markedly exacerbated airway remodeling and promoted airway hyperresponsiveness (AhR). The study suggest...
