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Inhibition of succinate-ubiquinone reductase by nitrosalicyl-N-alkylamides

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成果类型:
期刊论文
作者:
LIU, C;XU, JX;XIAO, Y;GU, LQ
通讯作者:
Xu, J.-x.
作者机构:
ACAD SINICA,INST BIOPHYS,BEIJING 50052728,PEOPLES R CHINA.
HUAZHONG NORMAL UNIV,INST ORGAN SYNTH,WUHAN,PEOPLES R CHINA.
ZHONGSHAN UNIV,DEPT CHEM,GUANGZHOU,PEOPLES R CHINA.
[GU, LQ] Department of Chemistry, Zhongshan University, Guanzhou (China), China
[LIU, C; XU, JX] Institute of Biophysics, Academia Sinica, Beijing (China), China
语种:
英文
关键词:
2,6-dicholoroindophenol;2-thenoyl-trifluoroacetone;3-Nitrosalicyl-N-alkylamide;DCIP;Enzyme inhibition;heart muscle preparation;HMP;Q2;Q2H2;Q2H2-cytochrome c reductase;QCR;QPs;Respiratory chain;SCR;SDH;SQR;succinate dehydrogenase;succinate-cytochrome c reductase;Succinate-ubiquinone reductase;succinate-ubiquinone reductase;TTFA;ubiquinol;ubiquinone;ubiquinone-binding protein in SQR
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
ISSN:
0005-2728
年:
1991
卷:
1057
期:
3
页码:
373-376
基金类别:
This work was supported by the Chinese National Science Foundation (3880200).
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
The abilities of eight nitrosalicyl-N-alkylamides to inhibit succinate-ubiquinone reductase were compared. These compounds possess both a nitro group at 3- or 5-position of the benzyl ring, and a methyl, decyl, dodecyl or tetradecyl group substituted for the amide hydrogen of salicylamide. The result shows the following: (a) 3-Nitrosalicyl-N-alkylamides are stronger inhibitors than 5-nitrosalicyl-N-alkylamides when they have the same alkyl group. (b) The inhibitory abilities of both 3-and 5-nitrosalicyl-N-alkylamides increase with increasing al...

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