期刊论文

中文

分子科学学报

1000-9035

2007

23

5

312-315

10.3969/j.issn.1000-9035.2007.05.003

国家自然科学基金资助项目（30670429）和湖北省自然科学基金资助项目（2006ABA179）；

本校为第一机构

采用X射线衍射的方法,解析得到MLLSET主要由β二级结构单元组成,组织成2个结构单元,形成1个大致L形状,每个臂大约5.0 nm长.构成N结构域的140个残基组织成一个重复的反平行β结构,由12个反平行β链组成,大约长5.0 nm,宽3.0nm,高2.0 nm.第一个转角把第一和第二条链联系起来,是短而紧密的,但链3-4、链5-6和链7-8之间的连接环逐渐越来越延长,导致β7～β8转角中有8个残基.与β片层本身扭曲组合在一起,这些在片层一端的转角就产生了U形的槽,与链的方向大致垂直.,解析MLLSET结构域蛋白质的晶体结构,为通过分子设计的方法制备合适的药物,治疗白血病,打下坚实的基础.

MLLSET is largely comprised of β secondary structure elements and is organized into two structural domains＇that form an approximate L shape, each arm being about 5.0 nm long. The 140 residues that make up the N domain are organized into a repeating antiparallel β structure. The N domain is made up of 12 antiparallel βstrands and is approximately 5. 0 nm long, 3.0 nm wide, and 2. 0 nm deep. The first turn, connecting the first and second strands, is short and tight, but the connecting loops between strands 3--4,5--6, and 7--8 become progress...