期刊论文

Jiang Lili

中文

有机化学

0253-2786

2009

29

9

1392-1404

20702018:国家自然科学基金 2007CB11630:国家重点基础研究发展计划（973计划）

本校为第一且通讯机构

2-巯基-5,7-二甲基-1,2,4-***并[1,5-α]嘧啶(6)与氯乙醛或氯丙酮反应生成5,7-二甲基-1,2,4.***并[1,5-α]嘧啶-2-硫丙酮(硫乙醛)(7).中间体7与D-烷基(芳基)羟胺(5)反应得到目标化合物1-(5,7-二甲基-1,2,4***[1,5-α]嘧啶-2-硫)乙醛-O-烷基肟醚(9),2-(5,7-二甲基-1,2,4***[1,5-α]嘧啶-2-硫)内酮O-烷基肟醚(10).初步生物活性测试结果表明部分化合物具有较好的除草活性.

2-Mercapto-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (6) was reacted with chloroacetaldehyde or 1-chloropropan-2-one to yield 5,7-dimethyl-1,2,4- triazolo[1,5-a]pyrimidin-2-ylsulfanyl-acetaldehyde or 1-(5,7-dimethyl-1,2,4- triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-propan-2-one) (7). The title compounds 1-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)propan-2-one O-methyl oxime (9) and 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio) acetaldehyde O-methyl oxime (10) were synthesized by the reaction of compound 7 with O-alkyl hydroxylamine 5. The primarily bioassay results show...