We propose a rapid ground-state optomechanical cooling scheme in a hybrid system, where a two-level quantum dot (QD) is placed in a single-mode cavity and a nanomechanical resonator (NMR) is also coupled to the cavity via radiation pressure. The cavity is driven by a weak laser field while the QD is driven by another weak laser field. Due to the quantum destructive interference arisen from different transition channels induced by simultaneously driving the QD-cavity system in terms of the two different lasers, two-photon absorption for the cavity field can be effectively eliminated by performi...