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Knockdown of RpL36 in testes impairs spermatogenesis in Drosophila melanogaster

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成果类型:
期刊论文
作者:
Fang, Yang;Zong, Qiong;He, Zhen;Liu, Chen;Wang, Yu-Feng*
通讯作者:
Wang, Yu-Feng
作者机构:
[Fang, Yang; He, Zhen; Zong, Qiong; Wang, Yu-Feng] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Sch Life Sci, Wuhan 430079, Peoples R China.
[Liu, Chen] Wuhan Univ Sci & Technol, Inst Biol & Med, Wuhan, Peoples R China.
通讯机构:
[Wang, Yu-Feng] C
Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Sch Life Sci, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Drosophila melanogaster;JAK/STAT pathway;RpL36;cell cycle;cell death;spermatogenesis
期刊:
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
ISSN:
1552-5007
年:
2021
卷:
336
期:
5
页码:
417-430
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31672352, 31872288]; Open Project of Hubei Key Laboratory of Genetic Regulation and Integration Biology [GRIB201907]
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Many ribosomal proteins (RPs) not only play essential roles in ribosome biogenesis, but also have “extraribosomal” functions in various cellular processes. RpL36 encodes ribosomal protein L36, a component of the 60S subunit of ribosomes in Drosophila melanogaster. We report here that RpL36 is required for spermatogenesis in D. melanogaster. After showing the evolutionary conservation of RpL36 sequences in animals, we revealed that the RpL36 expression level in fly testes was significantly higher than in ovaries. Knockdown RpL36 in fly testes ...

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