In order to explore the molecular regulation of GSNO reductase (GSNOR), effects of environmental formaldehyde exposure and antioxidant alpha-lipoic acid (LA) injection on GSNOR activity and expression in mice lungs were investigated in the present study. Results showed that GSNOR activity was elevated upon 3.0 mg/m(3) FA exposure (compared with 0 mg/m(3) FA inhaled group, p