期刊论文

中文

化学与生物工程

1672-5425

2016

33

11

15-20,26

10.3969/j.issn.1672-5425.2016.11.003

国家自然科学基金重点项目（21577045）；

本校为第一机构

为研究纳米二氧化钛(nano-TiO2)对小鼠脑和血管的毒性,将56只小鼠随机分为8组,每组7只,分别为control、solvent control、4 mg·kg-1 nano-TiO2、20 mg·kg-1 nano-TiO2、100 mg·kg-1 nano-TiO2、500 mg·kg-1 nano-TiO2、100 mg·kg-1维生素 E(VE)+100 mg·kg-1 nano-TiO2和100 mg·kg-1 VE+500 mg·kg-1 nano-TiO2,采用皮肤涂抹的方式,对小鼠进行连续42 d 暴露。结果表明：4 mg·kg-1 nano-TiO2和20 mg·kg-1 nano-TiO2对小鼠的大脑毒性和血管损伤较低,100 mg·kg-1 nano-TiO2和500 mg·kg-1 nano-TiO2对小鼠的大脑毒性和血管损伤明显,暴露中VE 的添加对 nano-TiO2给脑和血管造成的损伤具有一...

To investigate toxic effects of nano-TiO2 on brain and blood vessel of mice,56 BALB/c mice were randomly divided into 8 groups,including control, solvent control,4 mg·kg^-1 nano-TiO2,20 mg·kg^-1 nano- TiO2,100 mg ·kg^-1 nano-TiO2,500 mg·kg^-1 nano-TiO2,100 mg ·kg^-1 VE＋100 mg ·kg^-1 nano-TiO2 and 100 mg ·kg^-1 VE＋500 mg ·kg^-1 nano-TiO2 ,with 7 mice in each group. Mice were continuously exposed to nano-TiO2 by dermal exposure for 42 days. The results showed that, the brain and blood vessel of mice in 4 mg ·kg^-1 nano-TiO2 and 20 mg ·...