An Activity-Based Fluorogenic Probe Enables Cellular and in Vivo Profiling of Carboxylesterase Isozymes

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Shi-Yu;Qu, Ren-Yu;Li, Rong-Rong;Yan, Yao-Chao;Sun, Yao;...

通讯作者：

Yang, Wen-Chao;Yang, Guang-Fu（杨光富）

作者机构：

[Yang, Guang-Fu; Liu, Shi-Yu; Li, Rong-Rong; Yang, Wen-Chao; Qu, Ren-Yu; Yan, Yao-Chao; Sun, Yao; Yang, WC; Yang, GF] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ,Int Joint Res Ctr Intelligent Biosens, Wuhan 430079, Peoples R China.

[Yang, Guang-Fu; Liu, Shi-Yu; Li, Rong-Rong; Yang, Wen-Chao; Qu, Ren-Yu; Yan, Yao-Chao; Sun, Yao; Yang, WC; Yang, GF] Cent China Normal Univ, Coll Chem, Chem Biol Ctr, Wuhan 430079, Peoples R China.

[Yang, Guang-Fu] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30071, Peoples R China.

通讯机构：

[Yang, Guang-Fu; Yang, WC; Yang, GF] C

Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ,Int Joint Res Ctr Intelligent Biosens, Wuhan 430079, Peoples R China.

Cent China Normal Univ, Coll Chem, Chem Biol Ctr, Wuhan 430079, Peoples R China.

Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 30071, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2020

卷：

期：

页码：

9205-9213

DOI：

10.1021/acs.analchem.0c01554

基金类别：

National Key Research and Development Program of China [2017YFA0505200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21837001, 21977036]; Hubei Province Natural Science FoundationNatural Science Foundation of Hubei Province [2018CFA072]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Carboxylesterases (CEs) exist as multiple types of isomers in humans, and two major types are CE1 and CE2. They are widely distributed in human tissues and well-known for their important roles in drug metabolism and pathology of various diseases. Thus, the detection of CEs in living systems could provide efficient proof in disease diagnostics, as well as important information regarding chemotherapeutic effects of antitumor drugs and prognosis. To develop a specific probe to discriminate CEs from other hydrolases, especially cholinesterases, is ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

An Activity-Based Fluorogenic Probe Enables Cellular and in Vivo Profiling of Carboxylesterase Isozymes

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问