Ultrasensitive Determination of Sugar Phosphates in Trace Samples by Stable Isotope Chemical Labeling Combined with RPLC-MS

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成果类型：

期刊论文

作者：

Li, Sha;Liu, Fei-Long;Zhang, Zheng;Yin, Xiao-Ming;Ye, Tian-Tian;...

通讯作者：

Feng, YQ

作者机构：

[Yin, Xiao-Ming; Yuan, Bi-Feng; Feng, Yu-Qi; Liu, Fei-Long; Feng, YQ; Li, Sha; Ye, Tian-Tian] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China.

[Zhang, Zheng] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.

[Zhang, Zheng] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

[Yuan, Bi-Feng; Feng, Yu-Qi; Feng, YQ] Wuhan Univ, Sch Publ Hlth, Wuhan 430071, Peoples R China.

通讯机构：

[Feng, YQ ] W

Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China.

Wuhan Univ, Sch Publ Hlth, Wuhan 430071, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2022

卷：

期：

页码：

4866-4873

DOI：

10.1021/acs.analchem.2c00346

基金类别：

National Key Research and Development Program of China [2018YFA0900400]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21635006, 21721005]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Sugar phosphates are important metabolic intermediates in organisms and play a vital role in energy and central carbon metabolism. Profiling of sugar phosphates is of great significance but full of challenges due to their high structural similarity and low sensitivities in liquid chromatography (LC)-mass spectrometry (MS). In this study, we developed a novel stable isotope chemical labeling combined with the reversed-phase (RP)LC-MS method for ultrasensitive determination of sugar phosphates at the single-cell level. By chemical derivatization ...

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Ultrasensitive Determination of Sugar Phosphates in Trace Samples by Stable Isotope Chemical Labeling Combined with RPLC-MS

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