Embedding Proteins within Spatially Controlled Hierarchical Nanoarchitectures for Ultrasensitive Immunoassay

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成果类型：

期刊论文

作者：

Su, Dandan;Li, Hongxia;Zhou, Ri;Zhao, Lianjing;Li, Aixin;...

通讯作者：

Yan, Xu;Lu, GY;Zhu, CZ

作者机构：

[Yan, Xu; Liu, Xiaomin; Liu, Fangmeng; Wang, Chenguang; Sun, Peng; Lu, Geyu; Su, Dandan; Zhao, Lianjing; Yan, X; Li, Aixin; Zhou, Ri; Jia, Xiaoteng] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China.

[Li, Hongxia] Jilin Univ, Coll Food Sci & Engn, Dept Food Qual & Safety, Changchun 130062, Peoples R China.

[Zhu, Chengzhou; Zhu, CZ] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.

通讯机构：

[Yan, X; Lu, GY ] J

[Zhu, CZ ] C

Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China.

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2022

卷：

期：

页码：

6271-6280

DOI：

10.1021/acs.analchem.2c00269

基金类别：

National Natural Science Foundation of China [62171194, 31901777, 21806051, 61831011, 61833006]; National Key Research and Development Program of China [2016YFC0207300]; China Post-doctoral Science Foundation [2020M670857, 2021M691217]; Natural Science Foundation of Jilin Province [20200201021JC, 20200201218JC]; Program for JLU Science and Technology Innovative Research Team [JLUSTIRT 2017TD-07]; Young Elite Scientists Sponsorship Program by CAST [2019QN RC001]; Fundamental Research Funds for the Central University, Interdisciplinary Innovation Cultivation Project of Jilin University [JLUXKJC2020315]; Graduate Innovation Fund of Jilin University [101832020CX169]

机构署名：

本校为通讯机构

院系归属：

化学学院

摘要：

Modulating the precise self-assembly of functional biomacromolecules is a critical challenge in biotechnology. Herein, functional biomacromolecule-assembled hierarchical hybrid nanoarchitectures in a spatially controlled fashion are synthesized, achieving the biorecognition behavior and signal amplification in the immunoassay simultaneously. Biomacromolecules with sequential assembly on the scaffold through the biomineralization process show significantly enhanced stability, bioactivity, and utilization efficiency, allowing tuning of their func...

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Embedding Proteins within Spatially Controlled Hierarchical Nanoarchitectures for Ultrasensitive Immunoassay

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