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SERS Multiplex Profiling of Melanoma Circulating Tumor Cells for Predicting the Response to Immune Checkpoint Blockade Therapy

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成果类型:
期刊论文
作者:
Li, Junrong;Wuethrich, Alain;Zhang, Zhen;Wang, Jing;Lin, Lynlee L.;...
通讯作者:
Wang, Jing(jing.wang@fjnu.edu.cn);Behren, Andreas(Andreas.Behren@onjcri.org.au);Wang, Yuling(yuling.wang@mq.edu.au);Trau, Matt(m.trau@uq.edu.au)
作者机构:
[Li, Junrong] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, R China, Wuhan 430079, Peoples R China.
[Wuethrich, Alain; Trau, Matt; Zhang, Zhen; Li, Junrong] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.
[Lin, Lynlee L.] Univ Queensland, Diamantina Inst, Dermatol Res Ctr, Brisbane, Qld 4102, Australia.
[Wang, Jing] Fujian Normal Univ, Key Lab OptoElect Sci & Technol Med, Fujian Prov Key Lab Photon Technol, Minist Educ, R China, Fuzhou 350007, Peoples R China.
[Behren, Andreas] La Trobe Univ, Oliva Newton John Canc Res Inst, Sch Canc Med, Heidelberg, Vic 3086, Australia.
通讯机构:
[Jing Wang] K
[Andreas Behren] O
[Yuling Wang] S
[Matt Trau] C
School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW2109, Australia<&wdkj&>Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD4072, Australia<&wdkj&>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD4072, Australia<&wdkj&>Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou350007, P. R. China<&wdkj&>Oliva Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, VIC3086, Australia<&wdkj&>Department of Medicine, University of Melbourne, Heidelberg, VIC3010, Australia
语种:
英文
期刊:
Analytical Chemistry
ISSN:
0003-2700
年:
2022
卷:
94
期:
42
页码:
14573-14582
基金类别:
National Natural Science Foundation of China [12074069, 22204055]; Australian Research Council [DP160102836, DP210103151]; Australian Government Research Training Program Scholarship; National Health and Medical Research Council [APP1173669]; Mark Hughes Foundation Brain Cancer Innovation Project Grants; HCRA Biomarkers and Targeted Therapies Flagship Program; NHMRC Peter Doherty Biomedical Fellowship [APP1111216]; Department of Health and Human Services acting through the Victorian Cancer Agency
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
Immune checkpoint blockade (ICB) therapy has achieved remarkable success in many cancers including melanoma. However, ICB therapy benefits only a small proportion of patients and produces severe side effects for some patients. Thus, there is an urgent need to identify patients who are more likely to respond to ICB therapy to improve outcomes and minimize side effects. To predict ICB therapy responses, we design a surface-enhanced Raman scattering (SERS) assay for multiplex profiling of circulating tumor cells (CTCs) under basal and interferon-γ...

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