High Accuracy of Clinical Verification of Electrohydrodynamic-Driven Nanobox-on-Mirror Platform for Molecular Identification of Respiratory Viruses

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成果类型：

期刊论文

作者：

Li, Junrong;Guan, Rui;Wuethrich, Alain;Yan, Mingzhe;Cheng, Jing;...

通讯作者：

Sun, Y;Wuethrich, A

作者机构：

[Guan, Rui; Sun, Yao; Li, Junrong; Liu, Guorong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

[Yan, Mingzhe] Huazhong Univ Sci & Technol, Wuhan Jinyintan Hosp, Tongji Med Coll, Wuhan 430023, Peoples R China.

[Cheng, Jing] Wuhan Univ Sci & Technol, Sch Publ Hlth, Wuhan 430072, Peoples R China.

[Zhan, Jianbo] Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Testing, Wuhan 430072, Peoples R China.

[Wuethrich, Alain; Trau, Matt; Wuethrich, A] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.

通讯机构：

[Wuethrich, A ] U

[Sun, Y ] C

Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2024

卷：

期：

页码：

4495-4504

DOI：

10.1021/acs.analchem.3c05120

基金类别：

ARC Fellowship [22204055, 22022404, 22074050, 22374055]; National Natural Science Foundation of China [2022CFA033, 2022CFB834]; National Natural Science Foundation of Hubei Province [CCNU22QN007]; Fundamental Research Funds for the Central Universities [YQ23202]; Guangxi Key Laboratory of Automatic Detecting Technology and Instruments [FL220100059]; ARC Fellowship [2010799]; Cancer Australia [APP1173669]; National Health and Medical Research Council [DP210103151]; Australian Research Council

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

The molecular detection of multiple respiratory viruses provides evidence for the rational use of drugs and effective health management. Herein, we developed and tested the clinical performance of an electrohydrodynamic-driven nanobox-on-mirror platform (E-NoM) for the parallel, accurate, and sensitive detection of four respiratory viral antigens. The E-NoM platform uses gold-silver alloy nanoboxes as the core material with the deposition of a silver layer as a shell on the core surfaces to amplify and enable a reproducible Raman signal readout that facilitates accurate detection. Additionally...

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High Accuracy of Clinical Verification of Electrohydrodynamic-Driven Nanobox-on-Mirror Platform for Molecular Identification of Respiratory Viruses

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