Dual-Functional AIE Fluorescent Probe for Visualization of Lipid Droplets and Photodynamic Therapy of Cancer

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成果类型：

期刊论文

作者：

Pei, Shizeng;Li, Haoyang;Chen, Linfeng;Nie, Gang;Wang, Huiling*;...

通讯作者：

Zhang, CH;Wang, Huiling;Liu, CR

作者机构：

[Pei, Shizeng; Zhang, Caihong; Zhang, CH; Li, Haoyang] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Peoples R China.

[Pei, Shizeng; Liu, Chunrong; Wang, Huiling; Chen, Linfeng; Wang, HL] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.

[Nie, Gang] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharm, Wuhan Childrens Hosp,Wuhan Maternal & Child Health, Wuhan 430016, Peoples R China.

通讯机构：

[Zhang, CH ] S

[Wang, HL; Liu, CR ] C

Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Peoples R China.

Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2024

卷：

期：

页码：

5615-5624

DOI：

10.1021/acs.analchem.4c00227

基金类别：

National Natural Science Foundation of China [22177065]; National Natural Science Foundation of China [2023-026]; Shanxi Scholarship Council of China; Hundred Talents Project of Shanxi Province

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Abnormal lipid droplets (LDs) are known to be intimately bound with the occurrence and development of cancer, allowing LDs to be critical biomarkers for cancers. Aggregation-induced emission luminogens (AIEgens), with efficient reactive oxygen species (ROS) production performance, are prime photosensitizers (PSs) for photodynamic therapy (PDT) with imaging. Therefore, the development of dual-functional fluorescent probes with aggregation-induced emission (AIE) characteristics that enable both simultaneous LD monitoring and imaging-guided PDT is essential for concurrent cancer diagnosis and tre...

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