[Ruan, Han-Li; Xie, Zuo-Ye; Chang, Jin-Ling; Peng, Xiao-Gang; Ruan, HL; Gan, Yu-Tian; Zhou, Yin-Hui] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.

[Gan, Yu-Tian] Xiangyang Hosp Tradit Chinese Med, Xiangyang 441000, Peoples R China.

[Meng, Xianggao] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.

[Li, Shu-Ming] Philipps Univ Marburg, Fachbereich Pharm, Inst Pharmazeut Biol & Biotechnol, D-35037 Marburg, Germany.

[Ruan, HL ] H

Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.

anthraquinone derivative;antimitotic agent;asperustin A;asperustin B;asperustin C;asperustin D;asperustin E;asperustin F;asperustin J;concanavalin A;cyclosporine;cytotoxic agent;immunosuppressive agent;interleukin 6;mycophenolate mofetil;natural product;unclassified drug;anthraquinone derivative;antineoplastic agent;immunosuppressive agent;animal cell;Article;Aspergillus ustus;B lymphocyte;biosynthesis;cell proliferation;circular dichroism;comparative study;controlled study;crystal;crystal structure;cytotoxicity;cytotoxicity assay;data analysis;drug isolation;drug structure;fractionation;high performance liquid chromatography;IC50;immunosuppressive treatment;lymphocyte proliferation;mouse;nonhuman;optical rotation;protein blood level;proton nuclear magnetic resonance;T lymphocyte;X ray crystallography;X ray diffraction;animal;Aspergillus;chemical structure;chemistry;drug effect;drug screening;human;isolation and purification;metabolism;Animals;Anthraquinones;Antineoplastic Agents;Aspergillus;Cell Proliferation;Crystallography, X-Ray;Drug Screening Assays, Antitumor;Humans;Immunosuppressive Agents;Interleukin-6;Mice;Molecular Structure;T-Lymphocytes

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