期刊论文

Yang, Guangfu;Li, Haibing

英文

Nature Communications

2041-1723

2019

10

1

1323

10.1038/s41467-019-09163-4

National Key Research and Development Program of China [2018YFD0200102, 2017YFA0505203]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21572076, 21772055, 21708012]; Nature Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2018CFB534]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; Wuhan scientific and technological projects [2015020101010079]; Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics [2017002]

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Endogenous nitric oxide (NO) is an important messenger molecule, which can directly activate K + transmission and cause relaxation of vascular smooth muscle. Here, inspired by the K + channel of smooth muscle cells, we report, a novel NO-regulated artificial nanochannel based on a spiro ring opening−closing reaction strategy. This nanofluidic diode system shows an outstanding NO selective response owing to the specific reaction between o-phenylenediamine (OPD) and NO on the channel surface with high ion rectification ratio (~6.7) and ion gatin...