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Synthesis and Evaluation of Halogenated 5-(2-Hydroxyphenyl)pyrazoles as Pseudilin Analogues Targeting the Enzyme IspD in the Methylerythritol Phosphate Pathway

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成果类型:
期刊论文
作者:
Wang, Jili;Zhou, Yaqing;Wang, Xiuwen;Duan, Lixia;Duan, Jiang;...
通讯作者:
Li, Weiguo;Zhang, Aidong(张爱东
作者机构:
[Zhang, Aidong; Zhou, Yaqing; Wang, Jili; Wang, Xiuwen; Li, Weiguo; Duan, Jiang; Li, WG; Duan, Lixia] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Li, WG; Zhang, AD] C
Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
MEP pathway;IspD;pseudilin;analogue;5-(2-hydroxyphenyl)pyrazole;synthesis;herbicide
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2020
卷:
68
期:
10
页码:
3071-3078
基金类别:
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (21472064 and 21772060).
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
This work reports halogenated 5-(2-hydroxyphenyl)pyrazoles as pseudilin analogues with the potential to target the enzyme IspD in the methylerythritol phosphate (MEP) pathway. Such analogues were designed using the bioisosteric replacement of the pseudilin core structure and synthesized via an efficient three-step route. With AtIspD-based screening and pre- and post-emergence herbicidal tests, these compounds were demonstrated to have considerable activities against AtIspD, with IC50 up to 3.27 μM, and against model plants rape and barnyard gr...

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