Fluctuation and noise propagation in phenotypic transition cascades of clonal populations

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成果类型：

期刊论文

作者：

Pei, Qi-ming*;Zhan, Xuan;Yang, Li-jian（贾亚）;Shen, Jian;Wang, Li-fang;...

通讯作者：

Pei, Qi-ming

作者机构：

[Yang, Li-jian; Kirunda, J. B.; Shen, Jian; Qui, Kang; Li, An-bang; Zhan, Xuan; Pei, Qi-ming; Wang, Li-fang; Yousif, A. A. M.; Liu, Ting] Cent China Normal Univ, Inst Biophys, Wuhan 430079, Peoples R China.

[Yang, Li-jian; Kirunda, J. B.; Shen, Jian; Qui, Kang; Li, An-bang; Zhan, Xuan; Pei, Qi-ming; Wang, Li-fang; Yousif, A. A. M.; Liu, Ting] Cent China Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.

[Pei, Qi-ming] Yangtze Univ, Sch Phys & Optoelect Engn, Jingzhou 434023, Peoples R China.

通讯机构：

[Pei, Qi-ming] C

Cent China Normal Univ, Inst Biophys, Wuhan 430079, Peoples R China.

语种：

英文

期刊：

Physical Review E

ISSN：

2470-0045

年：

2015

卷：

期：

页码：

012721

DOI：

10.1103/PhysRevE.92.012721

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11105059, 11105058, 20201260169, 11175068, 11474117]; Technology Creative Project of Excellent Middle and Young Team of Hubei Province [T201204]; [CCNU12A01011]

机构署名：

本校为第一且通讯机构

院系归属：

物理科学与技术学院

心理学院

摘要：

Quantitative modeling of fluctuations of each phenotype is a crucial step towards a fundamental understanding of noise propagation through various phenotypic transition cascades. The theoretical formulas for noise propagation in various phenotypic transition cascades are derived by using the linear noise approximation of master equation and the logarithmic gain. By virtue of the theoretical formulas, we study the noise propagation in bidirectional and unidirectional phenotypic transition cascades, respectively. It is found that noise propagation in these two phenotypic transition cascades evid...

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Fluctuation and noise propagation in phenotypic transition cascades of clonal populations

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