A Multifunctional Nanocarrier System for Highly Efficient and Targeted Delivery of Ketamine to NMDAR Sites for Improved Treatment of Depression

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成果类型：

期刊论文

作者：

Ge, Jing;Tan, Ronghua;Gao, Qian;Li, Rui;Xu, Pengxin;...

通讯作者：

Wang, S.;Zhou, L.;Wan, Y.

作者机构：

[Song, Hang; Zhou, Lei; Wang, Shenqi; Ge, Jing; Xu, Pengxin] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China.

[Wan, Ying; Tan, Ronghua] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China.

[Gao, Qian] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Key Lab Mol Biophys, Minist Educ, Wuhan 430074, Hubei, Peoples R China.

[Li, Rui] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.

通讯机构：

[Shenqi Wang; Lei Zhou; Shenqi Wang Shenqi Wang Shenqi Wang; Lei Zhou Lei Zhou Lei Zhou] C

[Ying Wan; Ying Wan Ying Wan Ying Wan] N

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074 P. R. China<&wdkj&>National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074 P. R. China

语种：

英文

关键词：

antidepressants;ketamine;multifunctional nanocarriers;RBC membranes;targeted therapy

期刊：

Advanced Healthcare Materials

ISSN：

2192-2640

年：

2023

卷：

期：

页码：

2300154-

DOI：

10.1002/adhm.202300154

基金类别：

J.G., R.T., and Q.G. contributed equally to this work. This study was funded by the National Key Research and Development Program of China (Grant No. 2017YFC1104402). The authors would like to thank Bin Yang for his assistance with the synthesis of the mesoporous silica nanoparticles.

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

A new type of ketamine (KA)‐loaded nanoparticle (AC‐RM@HA‐MS‐KA) with specific targeting capabilities is developed to improve the efficacy of KA treatment. They can sustainably accumulate at the N‐methyl‐d‐aspartate receptor sites, effectively alleviate depressive symptoms, circumvent KA‐induced addiction, and significantly improve cognitive functions. Abstract Ketamine (KA), commonly used as an anesthetic, is now widely studied as an antidepressant for the treatment of depression. However, due to its side effects, such as addiction and...

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A Multifunctional Nanocarrier System for Highly Efficient and Targeted Delivery of Ketamine to NMDAR Sites for Improved Treatment of Depression

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