期刊论文

中文

生态毒理学报

1673-5897

2008

3

2

206-208

Supported by China Key Technologies R＆D Program （No. 2006BAI19B05 No. 2006BAJ02A10） China National Natural Science Foundation （No. 30570799）

本校为第一机构

近年来邻苯二甲酸酯污染已成为中国一个重要的环境问题.为探讨邻苯二甲酸二乙基己酯（di-（2-ethylhexyl）phthalate,DEHP）在诱发哮喘方面的作用,及研制DEHP诱导大鼠哮喘模型,将32只Wistar大鼠随机分成4组（每组8只）：生理盐水对照组、卵清白蛋白（OVA）致敏组和2个DEHP染毒组,采用OVA致敏加激发的方法制作大鼠哮喘模型.2个DEHP染毒组大鼠每天分别进行0.7mg·kg^-1和70mg·kg^-1邻苯二甲酸二乙基己酯灌胃染毒,连续30d.OVA致敏组、DEHP染毒组大鼠均在第31～37天给予1%OVA雾化,诱发哮喘.第38天取肺脏做组织切片,进行分析.结果表明,与OVA组相比,DEHP染毒组气管壁增厚,细胞浸润增加,气道重塑,特别...

Phthalate pollution becomes an environmental health problem in China recent years. In order to investigate the potential role of di-(2-ethylhexyl) phthalate (DEHP)in the pathogenesis of asthma and to establish the animal models of DEHP-induced asthma, 32 Wistar rats in four experimental groups were exposed to: (I) saline, (2) ovalbumin (OVA), (3) OVA+DEHP (0.7mg·kg~(-1)·d~(-1)) and (4) OVA+DEHP (70mg·kg~(-1)·d~(-1)). DEHP exposure treatment in this study was undertaken by gastric gavages and done before and during the process of OVA immuniz...