期刊论文

中文

生态毒理学报

1673-5897

2018

13

3

87-93

10.7524/AJE.1673-5897.20171220001

科技部十三五国家重点研发计划（No.2017YFC0702700） 国家自然科学基金面上项目（No.21577045）

本校为第一机构

我国城市当前普遍存在室外大气PM_(2.5)与室内甲醛(FA)联合污染状况,二者均被报道在单独暴露下可以导致肺损伤并诱导和诱发哮喘的急性发作,但其联合污染的具体效应,以及分子机制目前尚不清楚。为探究PM_(2.5)和/或甲醛暴露对小鼠的肺损伤及其可能的机制,分别将雄性Balb/c小鼠分为以下6组:对照组,AZD8055组,PM_(2.5)组,FA组,PM_(2.5) +FA组,PM_(2.5) +FA+ AZD8055组。染毒结束后,观察肺组织病理学变化;检测肺组织氧化损伤,活性氧(reactive oxygen species, ROS),还原型谷胱甘肽(glutathione, GSH)和丙二醛(malondialdehyde, MDA)的含量,DNA损伤,DNA-蛋白质交联( DNA-protein crosslink,DPC)系数和...

Currently, the combined pollution of PM_(2.5) and indoor formaldehyde (FA) has become a common issue in main cities of China. The two pollutants have both been reported to induce the lung damage and worsen allergic asthma, while there is no knowledge that whether their combined exposure has synergistically toxicological effects and its molecular mechanisms remain unknown. In order to explore the influence and the underlying mechanisms of FA and PM_(2.5) on lung damage, male Balb/c mice were randomly divided into six groups: Control group, AZD80...