期刊论文

Effects of Perinatal Exposure of Acetyl Tributyl Bitrate on Cognitive Ability of Offspring Mice

中文

生态毒理学报

1673-5897

2021

16

05

249-258

10.7524/AJE.1673-5897.20201022004

贵州省普通高等学校科技拔尖人才支持计划（黔教合KY字[2018]083）；

本校为其他机构

研究不同剂量的增塑剂乙酰柠檬酸三丁酯（acetyl tributyl citrate, ATBC）围产期暴露对子代小鼠认知能力的影响及其机制。以C57BL/6小鼠为受试动物,小鼠合笼后,对受孕雌性小鼠进行随机分组,设置对照组、ATBC暴露组(2、20和200 mg·kg-1·d-1),在围产期每天进行灌胃暴露。通过Morris水迷宫实验和跳台实验对子代小鼠的认知能力进行检测,观察子代小鼠脑组织病理变化及胶质细胞激活情况。检测子代小鼠脑组织匀浆中神经递质5-羟基色胺（5-hydroxytryptamine, 5-HT）、乙酰胆碱（acetylcholine, ACh）、活性氧（reactive oxygen species, ROS）、丙二醛（malondialdehyde, MDA）和还原型谷胱甘肽（gl...

To investigate the effects of perinatal exposure of acetyl tributyl citrate (ATBC) on cognitive ability of offspring mice and the possible mechanism, C57BL/6 mice were used as experimental animals. Male mice were mated with female mice, the pregnant females were randomly divided into four groups and orally administered with drugs daily for the whole perinatal period. The groups were control group, ATBC exposure groups (2, 20 and 200 mg·kg~(-1)·d~(-1)). The cognitive ability of offspring mice was detected by Morris water maze test and step-dow...