期刊论文

Effects of Exercise Training on Serum Th1/Th2 Cytokine Balance in Rats Exposed to TCDD

中文

生态毒理学报

1673-5897

2021

16

03

200-207

10.7524/AJE.1673-5897.20200416001

北京体育大学自主科研课题（2017YB026）； 国家体育总局科研课题（2017B053）；

本校为其他机构

尽管规律运动可提高免疫功能,但运动对急性2,3,7,8-四氯二苯并对二噁英（TCDD）暴露导致的免疫抑制作用的影响尚不清楚。Th1/Th2细胞因子平衡是机体免疫平衡的标志之一。为探究运动对急性TCDD暴露大鼠血清Th1/Th2细胞因子平衡的影响,将28只8周龄雄性Wistar大鼠随机分为正常对照组（NC）、运动对照组（EC）、TCDD对照组（TC）和TCDD运动组（ET）。TC组和ET组腹腔注射TCDD（10μg·kg-1体重）,NC组和EC组腹腔注射等量玉米油。随后,EC组和ET组负重游泳（5%体重）,每天30 min,每周6 d,持续4周; NC和TC静养4周。实验结束后称体重、胸腺和脾湿重,计算其相对重量; Elisa法测试血清肿瘤坏死因子-α（TNF...

Although regular exercise could improve immune function,the effect of exercise on the immunosuppression induced by acute 2,3,7,8-tetrachlorodibenzo-p -dioxin(TCDD)exposure was not clear.Th1/Th2 cytokine balance is one of the markers of immune balance.To investigate the effect of exercise on the balance of serum Th1/Th2 cytokine in rats exposed to TCDD,twenty-eight,8-week,male Wistar rats were randomly divided into normal control group(NC),exercise control group(EC),TCDD control group(TC)and TCDD exercise group(ET).The rats in TC and ET groups w...