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Recent advances in chemical protein synthesis: method developments and biological applications

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成果类型:
期刊论文
作者:
Dong, Suwei;Zheng, Ji-Shen;Li, Yiming;Wang, Huan;Chen, Gong;...
通讯作者:
Liu, L
作者机构:
[Dong, Suwei] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
[Dong, Suwei] Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China.
[Tang, Shan; Zheng, Ji-Shen] Univ Sci & Technol China, Div Life Sci & Med, Hefei 230027, Peoples R China.
[Li, Yiming] Hefei Univ Technol, Engn Res Ctr Bioproc, Sch Food & Biol Engn, Minist Educ, Hefei 230009, Peoples R China.
[Wang, Huan] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210023, Peoples R China.
通讯机构:
[Liu, L ] T
Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.
语种:
英文
关键词:
chemical protein synthesis;solid-phase peptide synthesis;ligation reactions;post-translational modifications;mirror-image proteins;peptide drugs
期刊:
中国科学:化学英文版
ISSN:
1674-7291
年:
2024
页码:
1-37
基金类别:
National Key R&D Program of China [2022YFC3401500]; National Natural Science Foundation of China [22137005, 92253302, 22227810, 22177004, 92153301, 22321005, 22277020, 22022703, 22177108, 22377118, 92353302, 22177059, 22177035, 22277029, 22077036, 22077078, 92053108, 22277015]
机构署名:
本校为其他机构
院系归属:
化学学院
摘要:
The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes, the study of which necessitates advanced methods to produce proteins with precision and versatility. Chemical protein synthesis, a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins, has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery, including post-translationally modified proteins, proteins comprised of unnatural amino acids, as ...

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