期刊论文

Xiao, WJ

英文

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

0002-7863

2024

146

28

18892–18898

10.1021/jacs.4c07096

National Key R&D Program of China [2023YFA1507203, 2022YFA1506100]; National Natural Science Foundation of China [91956201, 22271113, 22271111, 21820102003]; Central China Normal University; Wuhan Institute of Photochemistry and Technology

本校为第一且通讯机构

Herein, we designed a reaction for the desymmetrization-addition of cyclopropenes to imines by leveraging the synergy between photoredox and asymmetric cobalt catalysis. This protocol facilitated the synthesis of a series of chiral functionalized cyclopropanes with high yield, enantioselectivity, and diastereoselectivity (44 examples, up to 93% yield and >99% ee). A possible reaction mechanism involving cyclopropene desymmetrization by Co-H species and imine addition by Co-alkyl species was proposed. This study provides a novel route to important chiral cyclopropanes and e...