Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lv, Jian;Hu, Yimeng;Li, Lili;He, Yuan;Wang, Jingjing;...

通讯作者：

Hu, YM;Tang, LX;Tong, JJ;Cai, CG;Wang, ZH

作者机构：

[Wang, Zhihua; Lv, Jian] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China.

[Guo, Ningning; Fang, Yu; Wang, Zhihua; Lv, Jian] Chinese Acad Med Sci, Fuwai Hosp, Shenzhen Key Lab Cardiovasc Dis, Shenzhen 518057, Peoples R China.

[Guo, Ningning; Fang, Yu; Wang, Zhihua; Lv, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Beijing, Peoples R China.

[Hu, Yimeng; Hu, YM] Zhengzhou Univ, Henan Prov Peoples Hosp, Peoples Hosp, Dept Endocrinol, Zhengzhou 450003, Henan, Peoples R China.

[Hu, Yimeng] Wuhan Univ, Renmin Hosp, Dept Endocrinol, Wuhan 430060, Peoples R China.

通讯机构：

[Hu, YM ] Z

[Tang, LX ] W

[Tong, JJ ; Wang, ZH ] C

[Cai, CG ] U

Zhengzhou Univ, Henan Prov Peoples Hosp, Peoples Hosp, Dept Endocrinol, Zhengzhou 450003, Henan, Peoples R China.

语种：

英文

关键词：

Aging;Biomarkers;FABP4;Metabolic disorders;Rejuvenation;Senescence

期刊：

METABOLISM-CLINICAL AND EXPERIMENTAL

ISSN：

0026-0495

年：

2023

卷：

142

页码：

155528

DOI：

10.1016/j.metabol.2023.155528

基金类别：

National Natural Science Foundation of China [32170763, 81722007, 82070231]; National Health Commission of China [2017ZX10304402001-008]; National Key~Ramp;D Program of China [2022YFA1104500]; CAMS Innovation Fund for Medical Sciences [2022-I2M-1-007, 2022-I2M-2-001]; National High Level Hospital Clinical Research Funding of China [2022-GSP-GG-7]; State Key Laboratory of Cardiovascular Disease of China [2022-ZD-03]; Shenzhen Fundamental Research Program [ZDSYS20200923172000001]; Shenzhen Science and Technology Innovation Commission [RCJC20210706091947009]; Guangdong Basic and Applied Basic Research Foundation [2022A1515012517]

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

INTRODUCTION: Aging is characterized by progressive metabolic dyshomeostasis that increases morbidity and mortality. Solutions for optimizing healthy aging are challenged by lacking appropriate biomarkers. Moreover, druggable targets to rejuvenate the aging-associated metabolic phenotypes remain unavailable. METHODS: Proteomics analysis was performed in a cohort of young and elderly adults. Circulating levels of insulin-like growth factor 1 (IGF-1) and fatty acid binding protein 4 (FABP4) were evaluated by ELISA. FABP4 was silenced in elderly mice by adeno-associated virus. Metabolic activitie...

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Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders

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