The radial-azimuthal instability of a hot two-temperature accretion disc with advectionis analyzed. After obtaining the dispersion equation, we find that advection and viscous forcehave an influence on the stability of acoustic modes, but not on the stability of thermal andviscous modes. We also find azimuthal perturbations to affect the stability of all the modes.This model may be useful in explaining the quasi-periodic or periodic lum...