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Fabrication of PNIPAM-chitosan/decatungstoeuropate/silica nanocomposite for thermo/pH dual-stimuli-responsive and luminescent drug delivery system

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成果类型:
期刊论文
作者:
Huang, Na;Wang, Jun*;Cheng, Xiaoyan;Xu, Yafei;Li, Wuke
通讯作者:
Wang, Jun
作者机构:
[Li, Wuke; Xu, Yafei; Cheng, Xiaoyan; Wang, Jun; Huang, Na] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构:
[Wang, Jun] C
Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Biocompatible;Dual-responsive;Chitosan;Luminescence;Drug delivery;Cells
期刊:
Journal of Inorganic Biochemistry
ISSN:
0162-0134
年:
2020
卷:
211
页码:
111216
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21571074]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU19TS013]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A luminescent and dual-stimuli-responsive nanocomposite based on mesoporous silica, poly (N-isopropylacrylamide)-chitosan and decatungstoeuropate was prepared. To fabricate the nanocomposite, the mesoporous silica nanoparticles were coated with thermo/pH dual-responsive poly (N-isopropylacrylamide)-chitosan and the luminescent decatungstoeuropate particles were grafted onto copolymers. The designed nanocarrier could show exhibit good red luminescence as well as obvious thermo/pH stimuli-responsive properties, which could be employed as a drug storage reservoir for the loading and release of an...

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