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Simultaneous detection of peroxynitrite and viscosity in diabetes by a dual response fluorescent probe

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成果类型:
期刊论文
作者:
Zhang, Jinzheng;Gong, Shenyi;Liu, Yijia;Zheng, Zhoupeng;Feng, Guoqiang
通讯作者:
Feng, GQ
作者机构:
[Zheng, Zhoupeng; Feng, Guoqiang; Feng, GQ; Zhang, Jinzheng; Liu, Yijia; Gong, Shenyi] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Feng, GQ ] C
Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Dual -channel fluorescent probe;Viscosity;Peroxynitrite;Mitochondria;Diabetes;In vivo imaging
期刊:
Sensors and Actuators B-Chemical
ISSN:
0925-4005
年:
2024
卷:
406
页码:
135432
基金类别:
CRediT authorship contribution statement Jinzheng Zhang: Writing – original draft, Methodology, Investigation, Formal analysis, Data curation. Shenyi Gong: Writing – original draft, Methodology, Investigation, Formal analysis, Data curation. Yijia Liu: Writing – original draft, Methodology, Formal analysis, Data curation. Zhoupeng Zheng: Writing – original draft, Methodology, Formal analysis, Data curation. Feng Guoqiang: Writing – review & editing, Supervision, Project administration, acquisition, Conceptualization.
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
Diabetes is a common metabolic disease worldwide, which often has serious complications and seriously threatens human health. Abnormal viscosity and peroxynitrite (ONOO-) concentration are closely related to diabetes. Herein, we report a fluorescent dual response probe AO, which can simultaneously detect the changes of viscosity and ONOO- in diabetes at dual fluorescence channels. AO sensitively responds to viscosity and ONOO- with significant emission signal changes at 710 nm and 645 nm, respectively. Moreover, AO selectively targets mitochondria and generates a new compound when detecting ON...

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