Design and application of learning activity is an important content in e-learning. The paper firstly analyzes the state of art in designing learning activities, including Simple Sequence specification, Educational Markup Language, Learning Design theory and so on. In aspect of the compounding application between learning activities and learning resources, the paper discusses the basic designing strategy of the learning activities, and builds up the model to integrate learning resources and learning tools into learning activities. Based on the related learning theory, a case is discussed to des...