期刊论文

Yang, Guang-Fu

英文

CHEMICAL BIOLOGY & DRUG DESIGN

1747-0277

2014

83

1

71-80

10.1111/cbdd.12199

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21102052, 20932005, 20925206, 20902034, 21272092]; Central China Normal University Fundamental Research [CCNU13F008]; National Key Technologies RD ProgramNational Key Technology R&D Program [2011BAE06B05]

本校为第一且通讯机构

Antimycin and cyazofamid are specific inhibitors of the mitochondrial respiratory chain and bind to the Qi site of the cytochrome bc 1 complex. With the aim to understand the detailed molecular inhibition mechanism of Qi inhibitors, we performed a comparative investigation of the inhibitory kinetics of them against the porcine bc 1 complex. The results showed that antimycin is a slow tight-binding inhibitor of succinate-cytochrome c reductase (SCR) with Ki = 0.033 ± 0.00027 nm and non-competitive inhibition with respect to cytochrome c. Cyazof...