Fabrication of Redox-Controllable Bioinspired Nanochannels for Precisely Regulating Protein Transport

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成果类型：

期刊论文

作者：

Tu, Le;Qiu, Sheng;Li, Yuntao;Chen, Xiaoya;Li, Junrong;...

通讯作者：

Xiong, Xiaoxing(xiaoxingxiong@whu.edu.cn);Sun, Yao(sunyaogbasp@ccnu.edu.cn);Li, Junrong(junrong.li@ccnu.edu.cn)

作者机构：

[Tu, Le; Li, Haibing; Li, Junrong; Sun, Yao] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.

[Tu, Le; Xiong, Xiaoxing; Qiu, Sheng; Li, Yuntao] Zhejiang Univ, Sch Med, Huzhou Cent Hosp, Affiliated Huzhou Hosp,Dept Neurosurg, Huzhou 313099, Peoples R China.

[Xiong, Xiaoxing; Li, Yuntao] Wuhan Univ, Remin Hosp, Dept Neurosurg, Wuhan 430079, Peoples R China.

[Chen, Xiaoya] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin 541199, Peoples R China.

[Han, Yunfeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China.

通讯机构：

[Junrong Li; Yao Sun] K

[Xiaoxing Xiong] D

Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou 313099, P.R. China<&wdkj&>Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

语种：

英文

关键词：

bioinspired nanochannel;protein transport;redox driven;pillar[5]arene;gating ratio

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2022

卷：

期：

页码：

27421-27426

DOI：

10.1021/acsami.2c05594

基金类别：

This work is supported by the Ministry of Science and Technology of China (2021YFA0716700), NSFC (22022404 and 22074050), supported by the Open Project Program of Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University (GKLBCN-2021106-01), and Open Foundation Project of Hubei Provincial Key Laboratory of Molecular Imaging (2020fzyx011).

机构署名：

本校为第一机构

院系归属：

化学学院

摘要：

Redox regulation is an inherent feature of nature and plays a crucial role in the transport of ions/small molecules. However, whether redox status affects the biomolecule transport remains largely unknown. To explore the effects of redox status on biomolecule transport, herein, we constructed a glutathione/glutathione disulfide (GSH/GSSG)-driven and pillar[5]arene (P5)-modified artificial nanochannel for protein transport. The results indicate that hemoglobin (Hb) protein is selectively and effectively transported across the GSH-driven P5-modif...

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Fabrication of Redox-Controllable Bioinspired Nanochannels for Precisely Regulating Protein Transport

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