In order to build gene regulatory network,we proposed an algorithm based on gene expression levels and network anti-delivery.The algorithm used the network anti-delivery idea to analyze indirect effect produced from the traditional correlated calculation methods,and added an norm penalty term for controlling network sparsity after considering the sparsity of regulatory networks.We use the algorithm on the E.coli experimental data.This method improves the edge predictive ability of the correlation analysis on the regulatory network,Pearson correlation coefficient increased by 6.42%,Spearman cor...