Hand, foot, and mouth disease (HFMD) is a contagious disease mainly caused by the enterovirus 71 (EV71) and coxsackievirus A 16 (CoxA16). The infectious of HFMD is mainly children. In this paper, we construct an SEIHRS model, simulate the HFMD data of infectious from 2012 to 2016, estimate the basic reproductive number each year from 2012 to 2016, predict the infectious number of HFMD in year 2017, compute the domain of vaccination rate on children and put forward the preventive measures and control strategy. The results of this paper can pr...