Thermodynamic database supports deciphering protein–nucleic acid interactions

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成果类型：

期刊论文

作者：

Mei, Long-Can;Hao, Ge-Fei;Yang, Guang-Fu

通讯作者：

Ge-Fei Hao<&wdkj&>Guang-Fu Yang

作者机构：

[Mei, Long-Can; Hao, Ge-Fei] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

[Hao, Ge-Fei] State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550000, China. Electronic address: gefei_hao@foxmail.com

[Yang, Guang-Fu] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address: gfyang@mail.ccnu.edu.cn

通讯机构：

[Ge-Fei Hao; Guang-Fu Yang] K

Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550000, China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China

语种：

英文

关键词：

binding affinity;bioinformatics;data set;protein–nucleic acid interactions;therapeutic oligonucleotides

期刊：

Trends in Biotechnology

ISSN：

0167-7799

年：

2023

卷：

期：

页码：

140-143

DOI：

10.1016/j.tibtech.2022.09.018

基金类别：

This work was supported by the National Natural Science Foundation of China ( 32125033 ).

机构署名：

本校为第一机构

院系归属：

化学学院

摘要：

The thermodynamics of protein–nucleic acid interactions (PNIs) is crucial for elucidating the mechanisms of molecular recognition and pathological consequences. The Protein–Nucleic Acid Thermodynamics Database (PNATDB) is a database containing experimentally determined thermodynamic parameters along with sequence, structural, and function data, whic...

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Thermodynamic database supports deciphering protein–nucleic acid interactions

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