Melatonin antagonizes ozone-exacerbated asthma by inhibiting the TRPV1 channel and stabilizing the Nrf2 pathway

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成果类型：

期刊论文

作者：

Chen, Yushan;Wu, Xiaoyu;Yang, Xu;Liu, Xudong;Zeng, Yan;...

通讯作者：

Li, J.

作者机构：

[Li, Jinquan; Chen, Yushan; Wu, Xiaoyu; Zeng, Yan] Wuhan Univ Sci & Technol, Sch Med, Brain Sci & Adv Technol Inst, Wuhan 430065, Peoples R China.

[Li, Jinquan; Yang, Xu] Wuhan Univ Sci & Technol, Sch Med, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan 430079, Peoples R China.

[Liu, Xudong] Moutai Inst, Dept Food Sci & Engn, Renhuai 564507, Peoples R China.

通讯机构：

[Li, J.] H

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, China

语种：

英文

关键词：

Allergic asthma;Melatonin;Nrf2 pathway;Ozone;TRPV1

期刊：

Environmental Science and Pollution Research

ISSN：

0944-1344

年：

2021

卷：

期：

页码：

59858-59867

DOI：

10.1007/s11356-021-14945-9

基金类别：

This work was funded by the National Natural Science Foundation of China (81903278), Hubei Provincial Department of Education Science Research Program (Q20191103) and Regular Undergraduate Institutions Nature Science Research Project of Guizhou Education Department (Technology top-notch talent support project QianjiaoheKYzi [2018] 083).

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Over the past few years, ozone has been identified as a potential risk factor for exacerbating asthma. However, few attempts have been made to prevent the progression of ozone-exacerbated asthma. This study investigated the attenuating effects of melatonin on ozone-aggravated allergic asthma, and explored the changes to the transient receptor potential vanilloid 1 (TRPV1)-nuclear factor erythroid-derived 2-related factor 2 (Nrf2) pathway associated with melatonin treatment. The levels of TRPV1 and calcitonin gene-related peptides (CGRP) in lung...

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Melatonin antagonizes ozone-exacerbated asthma by inhibiting the TRPV1 channel and stabilizing the Nrf2 pathway

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