A study was conducted to demonstrate the synthesis of a number of DNA crosslinking agents, such as bis(catechol) quaternary ammonium derives. It was found that these agents can crosslink DNA through an o-quinone intermediate, induced by oxidation. It was also found that these compounds are composed of two catechol monomers, acting as DNA cross-linking units and are joined by different linkers that act as DNA binding units. Positive charged linkers and quaternary ammonium derivatives were used in the study, to achieve high affinity to DNA. Aliphatic and aromatic chains were investigated, to det...
