High and low temperatures aggravate airway inflammation of asthma: Evidence in a mouse model

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成果类型：

期刊论文

作者：

Deng, Linjing;Ma, Ping;Wu, Yang;Ma, Yongsheng;Yang, Xu;...

通讯作者：

Deng, Qihong

作者机构：

[Deng, Qihong; Deng, Linjing] Cent S Univ, Sch Energy Sci & Engn, Changsha, Hunan, Peoples R China.

[Deng, Qihong] Cent S Univ, Sch Architecture & Art, Changsha, Hunan, Peoples R China.

[Ma, Yongsheng; Deng, Qihong] Cent S Univ, XiangYa Sch Publ Hlth, Changsha, Hunan, Peoples R China.

[Deng, Qihong] Zhengzhou Univ, Sch Publ Hlth, Zhengzhou, Henan, Peoples R China.

[Wu, Yang; Ma, Ping] Hubei Univ Sci & Technol, Lab Environm Immunol & Neurol Dis, Xianning 437100, Peoples R China.

通讯机构：

[Deng, Qihong] C

Cent S Univ, Sch Architecture & Art, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Airway inflammation;High temperature;Low temperature;Mouse asthma;TRP

期刊：

Environmental Pollution

ISSN：

0269-7491

年：

2020

卷：

256

页码：

113433

DOI：

10.1016/j.envpol.2019.113433

基金类别：

This work was supported by the National Natural Science Foundation of China ( 51576214 and 21777193 ) and the Key Research and Development Program of Hunan Province , China ( 2017SK2091 ). Appendix A

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Epidemiology suggests ambient temperature is the triggers and potential activator of asthma. The role of high and low temperatures on airway inflammation of asthma, and the underlying molecular mechanism are not yet understood. A mouse model of asthma was adopted in our experiment. The BALB/c mice were exposed at different temperature for 4h (2h in the morning and 2h in the afternoon) on weekday. The exposure temperatures were 10 degrees C, 24 degrees C and 40 degrees C. Ovalbumin (OVA) was used to sensitize the mice on days 14, 18, 22, 26, and 30, followed by an aerosol challenge for 30min fr...

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High and low temperatures aggravate airway inflammation of asthma: Evidence in a mouse model

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