National Natural Science Foundation of China [22101094]; National Natural Science Foundation of China [2021CFB223]; Natural Science Foundation of Hubei Province, China
机构署名：
本校为第一且通讯机构
院系归属：
化学学院
摘要：
Regioselective C-H amination of simple arenes is highly desirable, but accessing meta-sites of ubiquitous arenes has proven challenging due to the lack of both electronic and spatial preference. This study demonstrates the successful use of various privileged nitrogen-containing functionalities found in pharmaceutical compounds to direct meta-C-H amination of arenes, overcoming the long-standing requirement for a redundant directing group. The remarkable advancements in functional group accommodation for precise regiochemical control were achieved through the discovery of an unprecedented orga...
