期刊论文

Effect of ceftiofur hydrochloride on pharmacokinetics of matrine in rats

Zhao, C.

中文

中国中药杂志

China Journal of Chinese Materia Medica

1001-5302

2010

35

14

1859-1861

10.4268/cjcmm20101420

重庆市科委重大攻关项目(CSTC2008AA1001,CSTC2009CB1010)；

本校为其他机构

目的:研究盐酸头孢噻呋对苦参碱在大鼠体内药动学的影响.方法:采用HPLC-UV测定苦参碱单独给药组与盐酸头孢噻呋和苦参碱联合给药组中苦参碱在大鼠体内的血药浓度, 用DAS2.1.、1药动学程序处理苦参碱的血药浓度一时间数据对, 比较两者的药动学参数.结果:苦参碱单独给药组苦参碱的C_(mar)为21. 113 9 mg.L~(-1), T_(mar)为0.75h, t_(1/2a)为1.34h, t_(1/2a)为3.509h, AUC_(o_t)为90. 984mg.h~(-1).L~(-1), AUC_(0_x)为100.346mg.h~(-1).L~(-1).盐酸头孢噻呋和苦参碱联合给药组苦参碱的C_(max)为11. 707mg'L~(-1)T_(max)为0.917h, t_(l/2a)为1.598h, t_(1/2a)为3.247h, AUC_(o-t)为53.28mg.h~(-l)....

OBJECTIVE: To investigate the effect of ceftiofur hydrochloride on the pharmacokinetics of matrine in rats. METHOD: The rats were divided into two groups: one group was administrated with matrine only (control group) and the other was administrated with matrine in combination with ceftiofur hydrochloride. HPLC-UV method was used for determining the plasma concentration of matrine in both groups. The pharmacokinetic parameters were calculated from the plasma concentration-time data using the DAS 2. 1. 1 software program. RESULT: The main pharmacokinetic parameters for the control group were C(m...