期刊论文

Liu, K

英文

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS

1874-9399

2022

1865

2

194799

10.1016/j.bbagrm.2022.194799

This work was supported by funds from the National Natural Science Foundation of China (Number 31770834 ) and Central China Normal University (CCNU) from the college's basic research and operation of the Ministry of Education (MOE) (Number CCNU19TS084 ). Due to the limited space, we apologize to those whose original work could not be cited in our review. We also thank for the anonymous reviewers for their critical coments and suggestions.

本校为第一且通讯机构

Discovered two decades ago, Piwi-interacting RNAs (piRNAs) play critical roles in gene regulation, transposon element repression, and antiviral defense. Dysregulation of piRNAs has been noted in diverse human diseases including cancers. Recently, extensive studies have revealed that many more proteins are involved in piRNA biogenesis. This review will summarize the recent progress in piRNA biogenesis and functions, especially the molecular mechanisms by which piRNA biogenesis-related pr...